Methanol → 1-(1-Methyl-3-indolyl)cyclopentaneacetonitrile

HRID 1587716ノート

反応式

HRID 1587716 の反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2([CH:16]=O)[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:3]1.C(C1C=C(C(C)C)C=C(C(C)C)C=1S(NN)(=O)=O)(C)C.[C-:38]#[N:39].[K+].CO>O1CCCC1.O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2([CH2:16][C:38]#[N:39])[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:3]1

参加物

7

反応物 4

HCID 887MethanolHCID 9032Potassium CyanideHCID 3593332,4,6-TriisopropylbenzenesulphonohydrazideHCID 105612721-(1-Methyl-3-indolyl)cyclopentanecarbaldehyde

生成物 1

HCID 107524351-(1-Methyl-3-indolyl)cyclopentaneacetonitrile

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

2.9 g (0.0134 mol) of 1-(1-methyl-3-indolyl)-cyclopentanecarbaldehyde and 5 g (0.0166 mol) of 2,4,6-triisopropylbenzenesulphonohydrazide dissolved in 30 cm3 of tetrahydrofuran are stirred at room temperature for 3 hours. The tetrahydrofuran is thereafter evaporated off completely and 2.6 g (0.0402 mol) of potassium cyanide and 30 cm3 of methanol are added to the residue. The mixture is heated to reflux for 4.5 hours and then cooled, water is added and the mixture is extracted with dichloromethane. In succession, the organic extract obtained is washed with aqueous sodium hydrogen carbonate solution, dried over sodium sulphate and filtered and the solvent is evaporated off. The crude product thereby isolated is purified by chromatography on a silica gel column in dichloromethane and then, where appropriate, by flash chromatography using a 3:1 hexane/ethyl acetate mixture as eluent.

後処理

  1. customThe tetrahydrofuran is thereafter evaporated off completely
  2. temperatureThe mixture is heated
  3. temperatureto reflux for 4.5 hours
  4. temperaturecooled
  5. extractionthe mixture is extracted with dichloromethane
  6. extractionIn succession, the organic extract
  7. customobtained
  8. washis washed with aqueous sodium hydrogen carbonate solution
  9. dry with materialdried over sodium sulphate
  10. filtrationfiltered
  11. customthe solvent is evaporated off

出典と根拠

ORDレコード
ord-c69ebea46139456e88f2e5a007385928
出典データセット
uspto-grants-1993_06
特許番号
US05219859

反応ノート

読み込み中…