Sodium cyanoborohydride → 3-Chloro-4,5-dihydro-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine
反応式
[Cl:1][C:2]1[CH:3]=[N:4][N:5]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=3)=[CH:9][CH:8]=[N:7][C:6]=12.C([BH3-])#N.[Na+]>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[N:4][N:5]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=3)=[CH:9][CH2:8][NH:7][C:6]=12参加物
4
実験手順
A 13.3 g portion of 3-chloro-7-[3-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidine and 7 g of sodium cyanoborohydride in 150 ml of acetic acid, were reacted as described in Example 1, giving 6.7 g of 3-chloro-4,5-dihydro-7-[3-(trifluoromethyl) phenyl]pyrazolo[1,5-a]pyrimidine.
出典と根拠
- ORDレコード
- ord-804ba2c409dd42e7a95612b93671bd09
- 出典データセット
- uspto-grants-1993_06
- 特許番号
- US05219857
反応ノート
読み込み中…