Sodium Hydroxide → N-[2-(4-Carboxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine
反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH:14][CH2:15][CH:16]([OH:26])[C:17]2[N:18]=[C:19]([C:22]([F:25])([F:24])[F:23])[S:20][CH:21]=2)[CH3:13])=[CH:7][CH:6]=1)([O:3]C)=[O:2].[OH-].[Na+]>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH:14][CH2:15][CH:16]([OH:26])[C:17]2[N:18]=[C:19]([C:22]([F:24])([F:23])[F:25])[S:20][CH:21]=2)[CH3:13])=[CH:7][CH:6]=1)([OH:3])=[O:2]参加物
3
実験手順
Prepared analogously to Example 2 by reaction of N-[2-(4-carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine with 1N sodium hydroxide solution. After neutralisation with hydrochloric acid, the mixture is evaporated to dryness and the residue is treated with a mixture of ethyl acetate/ethanol=6:1. The extract is evaporated to dryness and the residue is triturated with 5 ml of water. The water is decanted off and the remaining residue is taken up in methanol, the solution is evaporated to dryness, and the residue is triturated with ether and filtered off with suction.
後処理
- customAfter neutralisation with hydrochloric acid, the mixture is evaporated to dryness
- additionthe residue is treated with a mixture of ethyl acetate/ethanol=6:1
- customThe extract is evaporated to dryness
- customthe residue is triturated with 5 ml of water
- customThe water is decanted off
- customthe solution is evaporated to dryness
- customthe residue is triturated with ether
- filtrationfiltered off with suction
出典と根拠
- ORDレコード
- ord-b024158f5008490da4f41500da016f97
- 出典データセット
- uspto-grants-1993_06
- 特許番号
- US05219852
反応ノート
読み込み中…