Acetic Anhydride → 3-Nitro-N-(acetyl)benzenesulfonamide

HRID 1588038ノート

反応式

HRID 1588038 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[C:14](OC(=O)C)(=[O:16])[CH3:15]>O1CCCC1>[N+:1]([C:4]1[CH:5]=[C:6]([S:10]([NH:13][C:14](=[O:16])[CH3:15])(=[O:11])=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 67138Benzenesulfonamide, 3-nitro-

生成物 1

HCID 189578003-Nitro-N-(acetyl)benzenesulfonamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 3-nitrobenzenesulfonamide (615 mg) in 10 ml of dry tetrahydrofuran was cooled to 0° C. and mixed with 0.34 ml of acetic anhydride and 166 mg of 4-N,N-dimethylaminopyridine. The reaction mixture was stirred for 30 minutes, quenched with 10% citric acid solution, and diluted with ethyl acetate. The reaction mixture was extracted with ethyl acetate. The organic extracts were washed with brine, dried, concentrated in vacuo to yield 946 mg of the title compound in pure form.

後処理

  1. customquenched with 10% citric acid solution
  2. additiondiluted with ethyl acetate
  3. extractionThe reaction mixture was extracted with ethyl acetate
  4. washThe organic extracts were washed with brine
  5. customdried
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-9387e865494f4e3ba1157d89058cb0af
出典データセット
uspto-grants-1993_06
特許番号
US05220018

反応ノート

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