HCID 15932585、化合物 → HCID 131717987、化合物
反応式
[C:1]([NH:4][C@@H:5]1[C@@H:10]([OH:11])[C@H:9]([OH:12])[C@@H:8]([CH2:13][OH:14])[O:7][C@H:6]1[O:15][C@H:16]1[C@@H:31]([O:32][C@@H:33]2[O:40][C@H:39]([CH2:41][OH:42])[C@@H:37]([OH:38])[C@H:35]([OH:36])[C@H:34]2[NH:43][C:44](=[O:46])[CH3:45])[C@@H:30]([CH2:47][OH:48])[O:29][C@@H:18]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])[C@@H:17]1[OH:49])(=[O:3])[CH3:2].C1C(=O)NC(=O)NC=1[C@@H]1O[C@H](COP(OP(O[C@H:73]2[O:78][C@H:77]([CH2:79][OH:80])[C@H:76]([OH:81])[C@H:75]([OH:82])[C@H:74]2[OH:83])(O)=O)(O)=O)[C@@H](O)[C@H]1O>[As](C)(C)(=O)[O-].[Na+].[Cl-].[Mn+2].[Cl-]>[C@@H:18]1([O:12][C@@H:9]2[C@@H:8]([CH2:13][OH:14])[O:7][C@@H:6]([O:15][C@H:16]3[C@@H:31]([O:32][C@@H:33]4[O:40][C@H:39]([CH2:41][OH:42])[C@@H:37]([O:38][C@@H:73]5[O:78][C@H:77]([CH2:79][OH:80])[C@H:76]([OH:81])[C@H:75]([OH:82])[C@H:74]5[OH:83])[C@H:35]([OH:36])[C@H:34]4[NH:43][C:44](=[O:46])[CH3:45])[C@@H:30]([CH2:47][OH:48])[O:29][C@@H:18]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])[C@@H:17]3[OH:49])[C@H:5]([NH:4][C:1](=[O:3])[CH3:2])[C@H:10]2[OH:11])[O:29][C@H:30]([CH2:47][OH:48])[C@H:31]([OH:32])[C@H:16]([OH:15])[C@H:17]1[OH:49]参加物
5
実験手順
A solution of compound 18 of Example 18 (60 mg), UDP-galactose, (145 mg), bovine galactosyltransferase (6.25 U) and bovine serum albumin (3 mg) in 30 mM sodium cacodylate buffer (5.25 mL, pH 7.0) containing manganese chloride (40 umol) was incubated at 37° C. for 22 h. The reaction mixture was diluted to 20 mL and purified as described in Example 21. Yield of the product was 47 mg. The structural identity of titled compound 24 was unanbiguously assigned by 1H- and 13C-n.m.r (see Tables 4 and 5, respectively).
後処理
- additionThe reaction mixture was diluted to 20 mL
- custompurified
出典と根拠
- ORDレコード
- ord-dc1755a4ffe84d0cad7055dad489b85c
- 出典データセット
- uspto-grants-1993_06
- 特許番号
- US05220008
反応ノート
読み込み中…