HCID 131718006、化合物 → methyl (Z)-7-{(1R)-(2R,5S)-2-(5,5-difluoro-4oxooctyl)-5-hydroxy-3-oxocylopentyl}hept-5-enoate

HRID 1588448ノート

反応式

HRID 1588448 の反応式
[F:1][C:2]([F:34])([CH2:31][CH2:32][CH3:33])[C:3](=[O:30])[CH2:4][CH2:5][CH2:6][C@H:7]1[C:11](=[O:12])[CH2:10][C@H:9]([O:13]C2CCCCO2)[C@@H:8]1[CH2:20]/[CH:21]=[CH:22]\[CH2:23][CH2:24][CH2:25][C:26]([O:28][CH3:29])=[O:27]>C(O)(=O)C.C1COCC1.O>[F:1][C:2]([F:34])([CH2:31][CH2:32][CH3:33])[C:3](=[O:30])[CH2:4][CH2:5][CH2:6][C@H:7]1[C:11](=[O:12])[CH2:10][C@H:9]([OH:13])[C@@H:8]1[CH2:20]/[CH:21]=[CH:22]\[CH2:23][CH2:24][CH2:25][C:26]([O:28][CH3:29])=[O:27]

参加物

5

反応物 1

HCID 131718006HCID 131718006、化合物

生成物 1

HCID 15200568methyl (Z)-7-{(1R)-(2R,5S)-2-(5,5-difluoro-4oxooctyl)-5-hydroxy-3-oxocylopentyl}hept-5-enoate

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

The diketone (42) (0.188 g) was dissolved in a mixed solvent of acetic acid, THF and water (3:1:1, 25 ml) and the resultant mixture was kept at 40° C. for 3.5 hours. The crude product obtained after the usual work-up was subjected to silicagel column chromatography to give the titled compound (43).

後処理

  1. customThe crude product obtained after the usual work-up

出典と根拠

ORDレコード
ord-6c6380588c694f2fa9d9eb972d5074c6
出典データセット
uspto-grants-1993_06
特許番号
US05221799

反応ノート

読み込み中…