Chlorosulfonic acid → 4-[(2,4-Dioxo-1,3-thiazolidin-5-yl)methyl]benzene-1-sulfonyl chloride

HRID 1588763ノート

反応式

HRID 1588763 の反応式
[Cl:1][S:2]([OH:5])(=O)=[O:3].[CH2:6]([CH:13]1[S:17][C:16](=[O:18])[NH:15][C:14]1=[O:19])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[S:17]1[CH:13]([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([S:2]([Cl:1])(=[O:5])=[O:3])=[CH:9][CH:8]=2)[C:14](=[O:19])[NH:15][C:16]1=[O:18]

参加物

3

反応物 2

HCID 24638Chlorosulfonic acidHCID 31570135-Benzyl-1,3-thiazolidine-2,4-dione

生成物 1

HCID 156164324-[(2,4-Dioxo-1,3-thiazolidin-5-yl)methyl]benzene-1-sulfonyl chloride

実験手順

Chlorosulfonic acid (5 ml) was cooled to 0° C. and the 5-benzyl-2,4-thiazolidinedione prepared above (9.6 mmol, 2.0 g) was added portionwise. The reaction mixture was stirred at room temperature for 0.5 hour and poured into ice (25 g). The solution was extracted with methylene chloride (2×50 ml) and the organic layers were dried (Na2SO4) and solvent removed in vacuo to afford title product which was used without further purification.

後処理

  1. additionwas added portionwise
  2. extractionThe solution was extracted with methylene chloride (2×50 ml)
  3. dry with materialthe organic layers were dried (Na2SO4) and solvent
  4. customremoved in vacuo

出典と根拠

ORDレコード
ord-351f6a27936e4d21ab80be4fcabd91a2
出典データセット
uspto-grants-1993_06
特許番号
US05223522

反応ノート

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