Triethylamine → HCID 54086681、化合物

HRID 1588923ノート

反応式

HRID 1588923 の反応式
[CH2:1]([NH:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].C(N(CC)CC)C.C1(N(C2CCCCC2)[C:27](=[O:36])[C:28]2[CH:33]=[CH:32][C:31]([Br:34])=[C:30](C)[CH:29]=2)CCCC1>C1COCC1>[CH2:1]([N:7]([CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1)[C:27](=[O:36])[C:28]1[CH:33]=[CH:32][C:31]([Br:34])=[CH:30][CH:29]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 4991888N-hexylcyclohexanamineHCID 19754882HCID 19754882、化合物

生成物 1

HCID 54086681HCID 54086681、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a cold (0° C. to 5° C.) stirred solution of N-n-hexyl-N-cyclohexyl amine (4.40 g, 24 mmol) and triethylamine (2.5 g, 24 mmol) in dry THF (50 mL) is added dropwise a solution of acid chloride (5.0 g, 23 mmol) in THF (20 mL). The reaction is stirred at room temperature overnight and worked up in the same manner as for 4-bromo-3-methylbenzoic acid N-cyclopentyl-N-cyclohexyl amide. The crude product is purified by either recrystallization or by chromatography on silica gel using mixtures of ethyl acetate and hexane as eluents.

後処理

  1. customThe crude product is purified by either recrystallization or by chromatography on silica gel using mixtures of ethyl acetate and hexane as eluents

出典と根拠

ORDレコード
ord-2dd6724e7fb2445789d6f5c53b17c67a
出典データセット
uspto-grants-1993_06
特許番号
US05223539

反応ノート

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