3-Methoxyaniline → N-(3-Methoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine hydrochloride

反応式

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:9])[CH:6]=[CH:7][CH:8]=1.Cl.[Cl:11][CH2:12][CH2:13][NH:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[ClH:11].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:9][CH2:12][CH2:13][NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:6]=[CH:7][CH:8]=1

参加物

反応物 2

HCID 108243-Methoxyaniline

HCID 13054189Benzenemethanamine, N-(2-chloroethyl)-, hydrochloride (1:1)

生成物 1

HCID 19755023N-(3-Methoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine hydrochloride

実験手順

Combine 3-methoxybenzenamine (81.2 g, 0.66 mol) with N-(2-chloroethyl)-benzenemethanamine hydrochloride (45.3 g, 0.22 mol) and heat to 190° C. for 13 h. Add methylene chloride to precipitate a solid. Filter the solid and wash with methylene chloride. Triturate the solid with 100 mL of ethanol, filter the solid and wash with ethanol to give the title compound.

後処理

customAdd methylene chloride to precipitate a solid
filtrationFilter the solid
washwash with methylene chloride
customTriturate the solid with 100 mL of ethanol
filtrationfilter the solid
washwash with ethanol

出典と根拠

ORDレコード: ord-b0834ac3418946d9a046cd9081bfe01f
出典データセット: uspto-grants-1993_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05223623

反応ノート

読み込み中…

参加物