Hydrochloric Acid → 2-Piperazinecarboxylic acid,4-phenyl-1-(phenylmethyl)-

HRID 1588980ノート

反応式

HRID 1588980 の反応式
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:9]([C:20](N)=[O:21])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:23].[K+].Cl.O>C(O)CO>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:9]([C:20]([OH:21])=[O:23])[CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 109900971-Benzyl-4-phenyl-piperazine-2-carboxamide

生成物 1

HCID 149988012-Piperazinecarboxylic acid,4-phenyl-1-(phenylmethyl)-

試薬・触媒・溶媒 1

HCID 174Ethylene Glycol溶媒

反応条件

温度
150 °C

実験手順

Suspend 4-phenyl-1-(phenylmethyl)-2-piperazinecarboxamide (14.5 g, 49 mmol) in ethylene glycol (400 mL) and add potassium hydroxide (27.5 g, 490 mmol). Heat this mixture to 150° C. for 18 h. After this time, remove the solvent in vacuo. Add 6M hydrochloric acid (81.5 mL, 0.49 mol) and water (300 mL) and filter the resultant solid to obtain the title compound.

後処理

  1. customAfter this time, remove the solvent in vacuo
  2. filtrationfilter the resultant solid

出典と根拠

ORDレコード
ord-6a44282423354bc5be620a297419ab21
出典データセット
uspto-grants-1993_06
特許番号
US05223623

反応ノート

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