Hydrochloric Acid → 4-(3-Aminophenyl)-1-(phenylmethyl)-2-piperazinecarboxamide

反応式

C([NH:4][C:5]1[CH:6]=[C:7]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:13]([C:24]([NH2:26])=[O:25])[CH2:12]2)[CH:8]=[CH:9][CH:10]=1)(=O)C.Cl.[OH-].[Na+]>CO>[NH2:4][C:5]1[CH:6]=[C:7]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:13]([C:24]([NH2:26])=[O:25])[CH2:12]2)[CH:8]=[CH:9][CH:10]=1

参加物

実験手順

To 4-[3-(acetylamino)phenyl]-1-(phenylmethyl)-2-piperazinecarboxamide (14.0 g, 39.9 mmol) in methanol (115 mL) add 6N aqueous hydrochloric acid (28 mL). Stir the reaction at reflux. Monitor the progress of the reaction by thin-layer chromatography. Upon completion of the reaction adjust the pH to 12 with 4N aqueous NaOH to obtain a white precipitate. Filter the precipitate to obtain the title compound.