Sodium Hydroxide → HCID 13588903、化合物

HRID 1589168ノート

反応式

HRID 1589168 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.Cl.Cl.[N:13]1([CH2:18][CH2:19][NH2:20])[CH:17]=[N:16][CH:15]=[N:14]1.[OH-].[Na+]>C(Cl)Cl>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:20][CH2:19][CH2:18][N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)=[O:7])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 14798Sodium Hydroxide2 回HCID 685154-Bromobenzoyl chlorideHCID 202483172-(1H-1,2,4-triazol-1-yl)ethan-1-amine dihydrochloride

生成物 1

HCID 13588903HCID 13588903、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A mixture of about 2.2 g of 4-bromobenzoyl chloride, about 1.85 g of 1H-1,2,4-triazole-1-ethanamine dihydrochloride, about 30 ml of approximately 1N sodium hydroxide and about 75 ml of methylene chloride was stirred overnight, then about 5 ml of approximately 1N sodium hydroxide and about 75 ml of methylene chloride were added. The layers were separated and the organic layer was concentrated to remove the solvent. The crystalline residue was washed onto a filter with ether giving the desired product, mp 160°-162° C.

後処理

  1. customThe layers were separated
  2. concentrationthe organic layer was concentrated
  3. customto remove the solvent
  4. washThe crystalline residue was washed onto
  5. filtrationa filter with ether giving the desired product, mp 160°-162° C.

出典と根拠

ORDレコード
ord-86262e30502a4fde9c5178cfcb9d3f25
出典データセット
uspto-grants-1986_02
特許番号
US04568685

反応ノート

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