Sodium Hydroxide → 4-Bromo-N-[3-(4-phenyl-1H-imidazol-1-yl)propyl]benzamide

HRID 1589179ノート

反応式

HRID 1589179 の反応式
[C:1]1([C:7]2[N:8]=[CH:9][N:10]([CH2:12][CH2:13][CH2:14][NH2:15])[CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].[Br:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1>C(Cl)Cl>[Br:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:15][CH2:14][CH2:13][CH2:12][N:10]2[CH:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[N:8]=[CH:9]2)=[O:24])=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 685154-Bromobenzoyl chlorideHCID 135889123-(4-Phenyl-1H-imidazol-1-yl)propan-1-amine

生成物 1

HCID 135889214-Bromo-N-[3-(4-phenyl-1H-imidazol-1-yl)propyl]benzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A mixture of 2.0 g. of 4-phenyl-1H-imidazole-1-propanamine, 50 ml. of methylenechloride and 10 ml. of 1N sodium hydroxide was stirred and 2.2 g. of 4-bromobenzoyl chloride was added. The mixture was stirred for eighteen hours, methylene chloride was added and the layers were separated. The organic layer was washed with water, dried over magnesium sulfate and concentrated. The residue was washed onto a filter with ether, giving the desired product, m.p. 132°-135° C.

後処理

  1. additionA mixture of 2.0 g
  2. customthe layers were separated
  3. washThe organic layer was washed with water
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated
  6. washThe residue was washed onto
  7. filtrationa filter with ether

出典と根拠

ORDレコード
ord-14ba947b417f4cf19189d66d73aa7c44
出典データセット
uspto-grants-1986_02
特許番号
US04568687

反応ノート

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