Benzyl Bromide → N-Benzyl-N-[3-(1H-imidazol-1-yl)propyl]benzamide

HRID 1589187ノート

反応式

HRID 1589187 の反応式
[N:1]1([CH2:6][CH2:7][CH2:8][NH:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[H-].[Na+].[CH2:20](Br)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CN(C)C=O>[CH2:20]([N:9]([CH2:8][CH2:7][CH2:6][N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1)[C:10](=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 3584880N-[3-(1H-imidazol-1-yl)propyl]benzamide

生成物 1

HCID 20248337N-Benzyl-N-[3-(1H-imidazol-1-yl)propyl]benzamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 4.58 g. of N-[3-(1H-imidazol-1-yl)propyl]benzamide, 40 ml. of dimethylformamide, and 0.96 g. of 50% sodium hydride in oil was stirred for 2 hours and 2.62 g. of benzyl bromide was added. The mixture was stirred for 24 hours, concentrated to remove the dimethyl formamide, diluted with water and methylene chloride, and the layers separated. The organic layer was washed with water, dried over magnesium sulfate, and concentrated. The oil was twice washed with hexane and again concentrated. The desired product was obtained as an oil.

後処理

  1. additionA mixture of 4.58 g
  2. concentrationconcentrated
  3. customto remove the dimethyl formamide
  4. additiondiluted with water and methylene chloride
  5. customthe layers separated
  6. washThe organic layer was washed with water
  7. dry with materialdried over magnesium sulfate
  8. concentrationconcentrated
  9. washThe oil was twice washed with hexane
  10. concentrationagain concentrated

出典と根拠

ORDレコード
ord-305cdc4c88134a4bb37b46b9121669d9
出典データセット
uspto-grants-1986_02
特許番号
US04568687

反応ノート

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