Acetic Anhydride → HCID 13577653、化合物

HRID 1589258ノート

反応式

HRID 1589258 の反応式
[Br:1][C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH:6]([CH3:13])[NH:7]2.[OH-].[Na+].[C:16](OC(=O)C)(=[O:18])[CH3:17]>S(=O)(=O)(O)O>[C:16]([N:7]1[C:8]2[C:3](=[C:2]([Br:1])[C:11]([F:12])=[CH:10][CH:9]=2)[CH2:4][CH2:5][CH:6]1[CH3:13])(=[O:18])[CH3:17]

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 14798Sodium HydroxideHCID 128968175-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

生成物 1

HCID 13577653HCID 13577653、化合物

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

反応条件

温度
20 °C

実験手順

To 6.0 g of 5-bromo-6-fluoro-1,2,3,4-tetrahydroquinaldine was added 50 ml of acetic anhydride and one drop of concentrated sulfuric acid. The solution was heated on a steam bath for two hours, then cooled to about 20° C. The solution was basified with 10% sodium hydroxide solution. The solution was extracted with chloroform, and the chloroform extracts were evaporated to provide an oil which was distilled in vacuo to provide N-acetyl-5-bromo-6-fluoro-1,2,3,4-tetrahydroquinaldine. The structural assignment was supported by nuclear magnetic resonance spectral analysis.

後処理

  1. temperatureThe solution was heated on a steam bath for two hours
  2. extractionThe solution was extracted with chloroform
  3. customthe chloroform extracts were evaporated
  4. customto provide an oil which
  5. distillationwas distilled in vacuo

出典と根拠

ORDレコード
ord-3462e399414a4d8297a1331466a7eb8c
出典データセット
uspto-grants-1986_02
特許番号
US04568750

反応ノート

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