4-(2-Methoxy-4-methylmercapto-benzoylamino)-5-nitro-1H-pyridin-2-one → 2-(2-Methoxy-4-methylmercapto-phenyl)-5H-imidazo[4,5-c]-pyridin-6-one

HRID 1589296ノート

反応式

HRID 1589296 の反応式
[CH3:1][O:2][C:3]1[CH:21]=[C:20]([S:22][CH3:23])[CH:19]=[CH:18][C:4]=1[C:5]([NH:7][C:8]1[C:13]([N+:14]([O-])=O)=[CH:12][NH:11][C:10](=[O:17])[CH:9]=1)=O>C(O)(=O)C.[Fe]>[CH3:1][O:2][C:3]1[CH:21]=[C:20]([S:22][CH3:23])[CH:19]=[CH:18][C:4]=1[C:5]1[N:14]=[C:13]2[CH2:12][NH:11][C:10](=[O:17])[CH:9]=[C:8]2[N:7]=1

参加物

4

反応物 1

HCID 135209344-(2-Methoxy-4-methylmercapto-benzoylamino)-5-nitro-1H-pyridin-2-one

生成物 1

HCID 704558092-(2-Methoxy-4-methylmercapto-phenyl)-5H-imidazo[4,5-c]-pyridin-6-one

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 176Acetic Acid溶媒

実験手順

0.6 g of crude 4-(2-methoxy-4-methylmercapto-benzoylamino)-5-nitro-1H-pyridin-2-one were dissolved in 10 ml of glacial acetic acid, the solution was mixed with two spatula tipsful of iron powder, and the mixture was stirred for 30 minutes at room temperature. The mixture was then refluxed for 20 minutes, filtered, and the filtrate was evaporated in vacuo. The product thus obtained were purified by chromatography on silica gel (eluant: methylene chloride/ethanol=100:2 to 100:15).

後処理

  1. temperatureThe mixture was then refluxed for 20 minutes
  2. filtrationfiltered
  3. customthe filtrate was evaporated in vacuo
  4. customThe product thus obtained
  5. customwere purified by chromatography on silica gel (eluant: methylene chloride/ethanol=100:2 to 100:15)

出典と根拠

ORDレコード
ord-18630330845a4e4cb0b76e3da355b2ef
出典データセット
uspto-grants-1986_02
特許番号
US04568680

反応ノート

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