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Sodium Hydroxide → Benzene, 1-((2-(4-chlorophenyl)-2-methylpropoxy)methyl)-3-(4-methylphenoxy)-

HRID 1589445
ノート
印刷プレビュー

反応式

HRID 1589445 の反応式
[OH-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([CH3:14])([CH3:13])[CH2:11][OH:12])=[CH:6][CH:5]=1.[CH3:15][C:16]1[CH:30]=[CH:29][C:19]([O:20][C:21]2[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=2)[CH2:24]Cl)=[CH:18][CH:17]=1>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.O>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]([CH3:14])([CH3:13])[CH2:11][O:12][CH2:24][C:23]2[CH:26]=[CH:27][CH:28]=[C:21]([O:20][C:19]3[CH:29]=[CH:30][C:16]([CH3:15])=[CH:17][CH:18]=3)[CH:22]=2)=[CH:8][CH:9]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 130345572-(4-Chlorophenyl)-2-methylpropanolHCID 202469851-(Chloromethyl)-3-(4-methylphenoxy)benzene

生成物 1

HCID 3067126Benzene, 1-((2-(4-chlorophenyl)-2-methylpropoxy)methyl)-3-(4-methylphenoxy)-収率 80%

試薬・触媒・溶媒 2

HCID 74236Tetrabutylammonium Bromide触媒
HCID 962
Water
溶媒

反応条件

温度
80 °C

実験手順

To 15.0 g of a 50% aqueous solution of NaOH were added 6.0 g of 2-(4-chlorophenyl)-2-methylpropyl alcohol, 8.1 g of 3-(4-methylphenoxy)benzyl chloride and 1.1 g of tetrabutyl ammonium bromide, and the mixture was stirred at 80° C. for 1 hour. The mixture was cooled to room temperature and water was added, and the mixture was extracted with toluene and the toluene extract was washed with water and dried over Na2SO4, and evaporated under reduced pressure, and the obtained crude ether was purified by column chromatography on 250 g of silica gel (1:1 mixed solvent of toluene and n-hexane was used as eluent) to give 9.9 g of the desired ether (the yield was 80% of the theoretical yield).

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. extractionthe mixture was extracted with toluene
  3. extractionthe toluene extract
  4. washwas washed with water
  5. dry with materialdried over Na2SO4
  6. customevaporated under reduced pressure
  7. customthe obtained crude ether
  8. customwas purified by column chromatography on 250 g of silica gel (1:1 mixed solvent of toluene and n-hexane was used as eluent)
  9. customto give 9.9 g of the desired ether (the yield was 80% of the
  10. customtheoretical yield)

出典と根拠

ORDレコード
ord-03d597e514ce48c4ab81d45effa0604a
出典データセット
uspto-grants-1986_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04570005

反応ノート

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