Hydrochloric Acid → 4-Hydroxy-3-nitrobenzene-1-carboximidamide

HRID 1589492ノート

反応式

HRID 1589492 の反応式
Cl.[C:2]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)(=[NH:4])[NH2:3].Cl.[N+:13]([O-])([OH:15])=[O:14].C(=O)([O-])O.[Na+]>S(=O)(=O)(O)O>[C:2]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([N+:13]([O-:15])=[O:14])[CH:6]=1)(=[NH:3])[NH2:4]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 944Nitric AcidHCID 217124Benzenecarboximidamide, 4-hydroxy-, hydrochloride (1:1)HCID 516892Sodium Bicarbonate

生成物 1

HCID 1355987304-Hydroxy-3-nitrobenzene-1-carboximidamide

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

To 20 ml of concentrated sulfuric acid, was added 7.6 g of 4-amidinophenol hydrochloride. When the evolution of hydrogen chloride gas had ceased, the solution was cooled in an ice-salt bath and 3.0 ml of nitric acid was slowly added to the solution while being stirred. The mixture was then stirred at room temperature for 20 to 30 minutes. The reaction mixture, orange in color, was diluted by pouring into a large volume of ice water. The diluted solution was added in small portions to a saturated aqueous sodium hydrogencarbonate solution to precipitate orange needle crystals. The crystals were collected by filtration and dried to obtain 7.6 g of 4-amidino-2-nitrophenol.

後処理

  1. temperaturethe solution was cooled in an ice-salt bath
  2. stirringThe mixture was then stirred at room temperature for 20 to 30 minutes
  3. additionThe reaction mixture, orange in color, was diluted
  4. customto precipitate orange needle crystals
  5. filtrationThe crystals were collected by filtration
  6. customdried

出典と根拠

ORDレコード
ord-ae7870d0e5ff47f69ab62f88b3a79180
出典データセット
uspto-grants-1986_02
特許番号
US04570006

反応ノート

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