1-Azido-4-[3-(1-piperidinylmethyl)phenoxy]-2-butanol → 1-Amino-4-{3-[(piperidin-1-yl)methyl]phenoxy}butan-2-ol

HRID 1589540ノート

反応式

HRID 1589540 の反応式
[N:1]([CH2:4][CH:5]([OH:22])[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:10]=1)=[N+]=[N-].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH2:1][CH2:4][CH:5]([OH:22])[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:10]=1

参加物

4

反応物 2

HCID 202460071-Azido-4-[3-(1-piperidinylmethyl)phenoxy]-2-butanolHCID 21226445Aluminium lithium hydride

生成物 1

HCID 202460151-Amino-4-{3-[(piperidin-1-yl)methyl]phenoxy}butan-2-ol収率 82%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 1-azido-4[3-(1-piperidinylmethyl)phenoxy]-2-butanol (10 g) in dry tetrahydrofuran (100 ml) was added dropwise to a stirred suspension of lithium aluminium hydride (4 g) in tetrahydrofuran (200 ml) under nitrogen. The resulting mixture was stirred at room temperature for 1 h and quenched with water (4 ml), followed by 15% sodium hydroxide (4 ml) and water (12 ml). The mixture was then filtered and the residue washed with tetrahydrofuran (50 ml). The combined filtrate was evaporated to give the title compound (7.5 g) as a pale pink oil.

後処理

  1. customquenched with water (4 ml)
  2. filtrationThe mixture was then filtered
  3. washthe residue washed with tetrahydrofuran (50 ml)
  4. customThe combined filtrate was evaporated

出典と根拠

ORDレコード
ord-1e1c9047d1924a8386466119e75d58e7
出典データセット
uspto-grants-1986_02
特許番号
US04571394

反応ノート

読み込み中…