Acetic Anhydride → HCID 20246370、化合物
反応式
[NH2:1][C:2]1[N:7]=[C:6]2[N:8]=[CH:9][CH:10]=[C:5]2[C:4](=[O:11])[N:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>N1C=CC=CC=1>[NH:1]([C:2]1[N:7]=[C:6]2[N:8]=[CH:9][CH:10]=[C:5]2[C:4](=[O:11])[N:3]=1)[C:12]([CH3:13])=[O:14]参加物
4
実験手順
2-Aminopyrrolo(2,3-d)pyrimidin-4-one (3.0 g) and acetic anhydride (10 g) are suspended in pyridine (50 ml) and the reaction is conducted under reflux for 24 hours. The solvent and excess reagent are distilled off under reduced pressure and, on an ice bath, 5% (W/V) alcoholic ammonia (20 ml) is added to the residue. The mixture is stirred for 2 hours. The resulting crystalline precipitate is collected by filtration and washed with dilute hydrochloric acid and water to give the above-identified compound (2.5 g).
後処理
- temperatureunder reflux for 24 hours
- distillationThe solvent and excess reagent are distilled off under reduced pressure and, on an ice bath
- addition5% (W/V) alcoholic ammonia (20 ml) is added to the residue
- filtrationThe resulting crystalline precipitate is collected by filtration
- washwashed with dilute hydrochloric acid and water
出典と根拠
- ORDレコード
- ord-7121e7973161421b9de70abbaca75120
- 出典データセット
- uspto-grants-1986_02
- 特許番号
- US04571423
反応ノート
読み込み中…