Thionyl Chloride → 2-(4-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoyl chloride
反応式
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:21]=[CH:20][C:13]([O:14][CH:15]([CH3:19])[C:16](O)=[O:17])=[CH:12][CH:11]=2)=[N:7][CH:8]=1.S(Cl)([Cl:26])=O>>[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:21]=[CH:20][C:13]([O:14][CH:15]([CH3:19])[C:16]([Cl:26])=[O:17])=[CH:12][CH:11]=2)=[N:7][CH:8]=1参加物
3
実験手順
13.1 g (0.04 mol) of 2-[4-(5-trifluoromethyl-2-pyridyloxy)phenoxy]propionic acid (prepared according to example 3 a)) are reacted with 31.4 g (0.25 mol, about 20 ml) of thionyl chloride by boiling under reflux while continuously introducing nitrogen and constantly stirring for 3 hours. After distilling off the excess thionyl chloride with exclusion of moisture under reduced pressure, a distillation residue is obtained which can be directly used for further transformation.
後処理
- temperatureunder reflux while continuously introducing nitrogen
- distillationAfter distilling off the excess thionyl chloride with exclusion of moisture under reduced pressure
- customa distillation residue is obtained which