Thionyl Chloride → 4-Acetoxy-3-fluorobenzoyl chloride
反応式
S(Cl)([Cl:3])=O.[C:5]([O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][C:10]=1[F:18])(=[O:7])[CH3:6]>CN(C)C=O.C1C=CC=CC=1>[C:5]([O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([Cl:3])=[O:14])=[CH:11][C:10]=1[F:18])(=[O:7])[CH3:6]参加物
5
実験手順
2.90 ml of thionyl chloride was added to 2.50 g (12.6 mM) of 4-acetoxy-3-fluorobenzoic acid. Under stirring at room temperature, two drops of N,N-dimethylformamide (DMF) was added thereto, followed by refluxing for 40 minutes. After the reaction, dry benzene was added to the reaction mixture, followed by two times of distilling-off of excessive thionyl chloride under reduced pressure to obtain 4-acetoxy-3-fluorobenzoyl chloride.
後処理
- temperatureby refluxing for 40 minutes
- additionwas added to the reaction mixture
出典と根拠
- ORDレコード
- ord-f410abdb5667411cb3a3f5b69161a42d
- 出典データセット
- uspto-grants-1993_04
- 特許番号
- US05200109
反応ノート
読み込み中…