Ethyl Acetate → 2-[(n-Butoxycarbonylmethyl)thio]thiazolo[5,4-b]pyridine

反応式

[SH:1][C:2]1[S:3][C:4]2[C:9]([N:10]=1)=[CH:8][CH:7]=[CH:6][N:5]=2.[CH2:11]([O:15][C:16](=[O:19])[CH2:17]Cl)[CH2:12][CH2:13][CH3:14].C(OCC)(=O)C>C(=O)([O-])[O-].[K+].[K+]>[CH2:11]([O:15][C:16]([CH2:17][S:1][C:2]1[S:3][C:4]2[C:9]([N:10]=1)=[CH:8][CH:7]=[CH:6][N:5]=2)=[O:19])[CH2:12][CH2:13][CH3:14]

参加物

実験手順

Twenty-four (24) g of 2-mercaptothiazolo[5,4-b]pyridine was dissolved in 300 ml of N,Ndimethylformamide, and 43.3 g of potassium carbonate and 23.65 g of chloroacetic acid n-butyl ester were added to the solution, followed by one-hour stirring at room temperature. Seven hundred (700) ml of ethyl acetate was added to the solution, which was then washed with water three times, dehydrated over magnesium sulfate, dried and distilled to remove the solvent to obtain the title compound (39.9 g, 99%).