クロロ酢酸ブチル

N-Butyl chloroacetatetyl ester (CAS# 590-02-3) was evaluated for acute oral toxicity in male and female Sprague-Dawley albino rats. The test substance was fed by oral gavage at dose levels of 251, 316, 398, and 501 mg/kg. The mortality ratios were 0/2 M, 0/3 F; 1/3 M, 1/2 F; 1/2 M, 2/3 F; and 3/3 M, 2/2 F, respectively. Toxic signs included reduced appetite and activity, rapidly increasing weakness, collapse, and death. Autopsy findings included hemorrhagic lungs and liver and acute gastrointestinal inflammation. The LD50 was determined to be 360 mg/kg.

N-Butyl chloroacetatetyl ester (CAS# 590-02-3) was evaluated for acute dermal toxicity in New Zealand white male and female rabbits at dose levels of 100, 200, 316, 501, and 1000 mg/kg. The mortality ratios were 0/1 F; 1/1 M, 1/1 F; 1/1 M, 1/1 F; 1/1 M; and 1/1 F, respectively. Toxic signs included reduced appetite and activity, rapidly increasing weakness, ocular discharge, collapse, and death. Autopsy findings included lung and liver hyperemia. The LD50 was determined to be greater than 200 mg/kg and less than 316 mg/kg.

N-Butyl chloroacetatetyl ester (CAS# 590-02-3) was evaluated for dermal irritation in three New Zealand white male and female rabbits at a dose level of 0.5 m/L applied undiluted to the intact skin. The test substance was a severe irritant with an average maximum score of 6.0 out of 8 in 24-hours. Observations following application included slight erythema and severe edema (24-hours) and no erythema or edema at 168-hours.

N-Butyl chloroacetatetyl ester (CAS# 590-02-3) was evaluated for eye irritation in three New Zealand white male and female rabbits at a dose level of 0.1 m/L. The test substance was classified as a mild eye irritation with an average maximum score of 16.6 out of 110 in 24-hours. Observations following application included moderate to severe erythema, including a diffuse, deep-crimson red appearance of the conjunctivae, with individual vessels not easily discernable; moderate edema; and moderate to copious discharge containing slight whitish exudate (24-hours). At 168-hours the eyes were normal with zero readings.

N-Butyl chloroacetatetyl ester (CAS# 590-02-3) was evaluated for acute inhalation toxicity in six male rats exposed for 6-hours at an average concentration of 2.8 g/m3. Observations during exposure included slight discomfort, but within 15-minutes the animals had normal reactions including no nasal or ocular discharge, no weakness or drowsiness, and normal respiration. Observations following exposure included normal respiration and no sign of toxic distress. All animals survived the 6-hour exposure. It was concluded that the vapors were practically non-toxic under conditions of the test.