Methanol → 2-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid

HRID 1589834ノート

反応式

HRID 1589834 の反応式
CO.[CH3:3][C:4]1[C:12]([C:13]([O:15]CC)=[O:14])=[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][N:6]2[N:5]=1>[OH-].[Na+]>[CH3:3][C:4]1[C:12]([C:13]([OH:15])=[O:14])=[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][N:6]2[N:5]=1

参加物

4

反応物 2

HCID 887MethanolHCID 12872285Ethyl 2-methylpyrazolo[1,5-a]pyridine-3-carboxylate

生成物 1

HCID 128722962-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid収率 52.4%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

A small amount of methanol was added to a solution of 0.356 g of ethyl 2-methyl-3-pyrazolo[1,5-a]-pyridinecarboxylate in 10 ml of 5N aq. NaOH solution, followed by stirring at room temperature for 24 hours. The reaction mixture was washed with benzene and then made acidic with concentrated hydrochloric acid. Crystals precipitated were collected by suction filtration. The crystals so obtained were dried and then recrystallized from benzene, whereby 0.16 g of the title compound was obtained (yield: 52.4%).

後処理

  1. washThe reaction mixture was washed with benzene
  2. customCrystals precipitated
  3. filtrationwere collected by suction filtration
  4. customThe crystals so obtained
  5. customwere dried
  6. customrecrystallized from benzene

出典と根拠

ORDレコード
ord-ffa7cb32f58540528db749a437ea17ad
出典データセット
uspto-grants-1993_04
特許番号
US05200415

反応ノート

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