Aniline → HCID 15022346、化合物

HRID 1589986ノート

反応式

HRID 1589986 の反応式
[Cl:1][C:2]1[C:3]([C:7](Cl)=[O:8])=[CH:4][S:5][CH:6]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O1CCOCC1.N1C=CC=CC=1>[Cl:1][C:2]1[C:3]([C:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:8])=[CH:4][S:5][CH:6]=1

参加物

5

反応物 2

HCID 6115AnilineHCID 129147964-Chlorothiophene-3-carbonyl chloride

生成物 1

HCID 15022346HCID 15022346、化合物

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 312751,4-Dioxane溶媒

実験手順

At room temperature, a solution of 4-chlorothiophene-3-carboxylic chloride (13.5 g, 0.075 mol) in 30 ml of dioxane is dripped into a solution of aniline (7.7 g, 0.083 mol) in pyridine (160 ml). The mixture is stirred for 12 hours at room temperature and concentrated to dryness, and the residue is taken up in dichloromethane. The organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water, dried and concentrated to dryness. Yield: 16.7 g, 94%; m.p. 119°-121° C.

後処理

  1. customAt room temperature
  2. concentrationconcentrated to dryness
  3. extractionThe organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water
  4. customdried
  5. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-91cd8de8eaff4b6d88abbb93493c924c
出典データセット
uspto-grants-1993_04
特許番号
US05201934

反応ノート

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