Sodium Hydroxide → sodium (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate monohydrate

HRID 1590190ノート

反応式

HRID 1590190 の反応式
[CH2:1]([C@@H:8]([CH2:12][C:13]([N:15]1[CH2:23][C@H:22]2[C@H:17]([CH2:18][CH2:19][CH2:20][CH2:21]2)[CH2:16]1)=[O:14])[C:9]([OH:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+:25]>C(O)C>[OH2:10].[CH2:1]([C@@H:8]([CH2:12][C:13]([N:15]1[CH2:16][C@H:17]2[C@H:22]([CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:23]1)=[O:14])[C:9]([O-:11])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[Na+:25]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 121891Mitiglinide

生成物 1

HCID 67758743sodium (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate monohydrate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid (1.38 g) in ethanol (5 ml) was added 2N sodium hydroxide solution (2.19 ml). After the solvent was evaporated under reduced pressure, the residue was crystallized from ethyl acetate to give 1.44 g of sodium (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate monohydrate.

後処理

  1. customAfter the solvent was evaporated under reduced pressure
  2. customthe residue was crystallized from ethyl acetate

出典と根拠

ORDレコード
ord-84ea975f100642eaa913f532cc042a2e
出典データセット
uspto-grants-1993_04
特許番号
US05202335

反応ノート

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