Hydroxyamine hydrochloride → 3-(Phenylethynyl)-benzaldehyde oxime

反応式

[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[CH:12]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:18][OH:19].C([O-])(=O)C.[Na+]>>[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[CH:12]=[N:18][OH:19])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

反応物 3

HCID 443297Hydroxyamine hydrochloride

HCID 517045Sodium Acetate

HCID 31450113-Phenylethynyl-benzaldehyde

生成物 1

HCID 727471633-(Phenylethynyl)-benzaldehyde oxime

実験手順

The procedure was the same as described in Example 1b, except there were used 16.5 g of 3-(phenylethynyl)-benzaldehyde, 8.3 g of hydroxylamine hydrochloride and 8.2 g of sodium acetate to give 16.8 g (94.8% of the theoretical yield) of the title compound in form of a yellowish powder (mixture of isomers).