Sodium Hydroxide → 1-methyl-4-(trifluoromethyl)-1H-pyrrole-3-carboxylic acid
反応式
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([F:10])([F:9])[F:8])[C:4]([C:11]([O:13]CC)=[O:12])=[CH:3]1.[OH-].[Na+]>C(O)C.O>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([F:9])([F:10])[F:8])[C:4]([C:11]([OH:13])=[O:12])=[CH:3]1参加物
5
実験手順
A mixture of ethyl 1-methyl-4-(trifluoromethyl)pyrrole-3-carboxylate (4.4 g, 0.02 mol) and 4N sodium hydroxide (5 ml, 0.02 mol) in ethanol is stirred for 24 hours at room temperature, diluted with water and extracted with ether. The aqueous phase is acidified with 10% HCl and filtered. The filter cake is washed with water and dried in vacuo at 45° C. to afford the title compound as an off-white solid, 2.4 g (62%), mp 210°-212° C.
後処理
- extractionextracted with ether
- filtrationfiltered
- washThe filter cake is washed with water
- customdried in vacuo at 45° C.
出典と根拠
- ORDレコード
- ord-fbf6ec8996884061aa6a11a9dc8e3317
- 出典データセット
- uspto-grants-1993_04
- 特許番号
- US05204332
反応ノート
読み込み中…