Hydrogen Bromide → HCID 14719549、化合物

HRID 1590822ノート

反応式

HRID 1590822 の反応式
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]([C:13]3[CH:18]=[CH:17][C:16]([O:19]C)=[C:15]([O:21]C)[CH:14]=3)[CH2:8][NH:9][CH2:10]2)=[CH:5][CH:4]=1.[BrH:23]>>[BrH:23].[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]([C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([OH:21])[CH:14]=3)[CH2:8][NH:9][CH2:10]2)=[CH:5][CH:4]=1

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 147195487-Methoxy-4-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

生成物 1

HCID 14719549HCID 14719549、化合物

実験手順

640 mg of 7-methoxy-4-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline was dissolved in 13 ml of 48% aqueous hydrogen bromide, and the mixture was heated under reflux under an argon gas stream for 3 hours. The reaction solution was cooled, and crystals which separated out were collected, affording 580 mg of 7-hydroxy-4-[3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux under an argon gas stream for 3 hours
  3. temperatureThe reaction solution was cooled
  4. customcrystals which separated out
  5. customwere collected

出典と根拠

ORDレコード
ord-52f4695cd387483182290cb6dd49549f
出典データセット
uspto-grants-1993_04
特許番号
US05204468

反応ノート

読み込み中…