Benzyl lactate → HCID 19768414、化合物

HRID 1590851

反応式

HRID 1590851 の反応式
[C:1](OCC1C=CC=CC=1)(=O)[CH:2]([CH3:4])O.[N:14](C(OCC)=O)=NC(OCC)=O.[CH2:26]([O:34][C:35]1[CH:40]=[CH:39][C:38]([C:41]2[CH:46]=[CH:45][C:44]([OH:47])=[CH:43][N:42]=2)=[C:37]([F:48])[CH:36]=1)[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]>>[CH2:26]([O:34][C:35]1[CH:40]=[CH:39][C:38]([C:41]2[CH:46]=[CH:45][C:44]([O:47][CH:2]([C:1]#[N:14])[CH3:4])=[CH:43][N:42]=2)=[C:37]([F:48])[CH:36]=1)[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]

参加物

4

反応物 3

HCID 98054Benzyl lactateHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 22717460HCID 22717460、化合物

生成物 1

HCID 19768414HCID 19768414、化合物

実験手順

Optically active benzyl lactate is etherified by means of diethyl azodicarboxylate (DEAD)/triphenylphosphine with 2-(4-octyloxy-2-fluorophenyl)-5-hydroxypyridine (prepared in accordance with Example 1) and the benzyl group is then split off hydrogenolytically. The acid so obtained is converted as usual into the nitrile (oxalyl chloride, ammonia, thionyl chloride). Optically active 2-(4-octyloxy-2-fluorophenyl)-5-(1-cyanoethoxy)-pyridine is obtained.

後処理

  1. customthe benzyl group is then split off hydrogenolytically
  2. customThe acid so obtained

出典と根拠

ORDレコード
ord-c13875652fd042b99e09cb22bf04964e
出典データセット
uspto-grants-1993_04
特許番号
US05204476

関連ノート

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