Hydrochloric Acid → HCID 19045366、化合物

HRID 1591184ノート

反応式

HRID 1591184 の反応式
C([NH:4][C:5]1[CH:6]=[CH:7][C:8]2[O:26][C:12]3([CH2:17][CH2:16][N:15]([CH2:18][C:19]4[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=4)[CH2:14][CH2:13]3)[CH2:11][CH2:10][C:9]=2[CH:27]=1)(=O)C.Cl.[OH-:29].[Na+]>CO>[NH2:4][C:5]1[CH:6]=[CH:7][C:8]2[O:26][C:12]3([CH2:13][CH2:14][N:15]([CH2:18][C:19]4[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=4)[CH2:16][CH2:17]3)[CH2:11][C:10](=[O:29])[C:9]=2[CH:27]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19045409HCID 19045409、化合物

生成物 1

HCID 19045366HCID 19045366、化合物収率 88%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 3,4-dihydro-6-acetamido-1'-(4-aminobenzyl)spiro[(2H)-1-benzopyran-2,4'-piperidine](136 mg, 0.36 mmol) and hydrochloric acid (6N solution, 13. 6 ml) in methanol (13.6 ml) was heated at reflux temperature for 1 hr. The reaction mixture was cooled to 0° C. and basified with 20% sodium hydroxide solution. Extraction with methylene chloride, drying and solvent evaporation gave 3,4-dihydro-6-amino-1'-(4-aminobenzyl)spiro[(2H)-1-benzopyran-2,4'-piperidine]-4-one (107 mg, 88%);

後処理

  1. temperatureat reflux temperature for 1 hr
  2. extractionExtraction with methylene chloride
  3. customdrying
  4. customsolvent evaporation

出典と根拠

ORDレコード
ord-a6482279ffbd4d76b98146c68738eead
出典データセット
uspto-grants-1993_04
特許番号
US05206240

反応ノート

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