2-Methoxyethanol → HCID 19045307、化合物
反応式
Cl[CH2:2][C:3]1[CH:4]=[CH:5][C:6]([OH:12])=[C:7]([C:9](=[O:11])[CH3:10])[CH:8]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:19][O:20][CH2:21][CH2:22][OH:23]>C(Cl)(Cl)Cl>[OH:12][C:6]1[CH:5]=[CH:4][C:3]([CH2:2][O:23][CH2:22][CH2:21][O:20][CH3:19])=[CH:8][C:7]=1[C:9](=[O:11])[CH3:10]参加物
5
実験手順
A mixture of 5'-(chloromethyl)-2'-hydroxyacetophenone (1.85 g, 10.0 mmol), potassium carbonate (1.38, 10.0 mmol), 2-methoxyethanol (0.9 g, 12.0 mmol) and 10 mL chloroform was stirred 24 hours, filtered, and the filtrate concentrated in vacuo to give a residue. The residue was purified by flash chromatography eluting with 30:70 ethyl acetate:hexane to give 0.40 g (18%) product as an oil.
後処理
- filtrationfiltered
- concentrationthe filtrate concentrated in vacuo
- customto give a residue
- customThe residue was purified by flash chromatography
- washeluting with 30:70 ethyl acetate
出典と根拠
- ORDレコード
- ord-9ee409a89967460192a5328b4f607644
- 出典データセット
- uspto-grants-1993_04
- 特許番号
- US05206240
反応ノート
読み込み中…