Cysteamine Hydrochloride → HCID 208627、化合物

HRID 1591246ノート

反応式

HRID 1591246 の反応式
Cl.[SH:2][CH2:3][CH2:4][NH2:5].[C:6]([O:10][CH2:11][CH3:12])(=[O:9])[CH:7]=O>>[S:2]1[CH2:3][CH2:4][NH:5][CH:7]1[C:6]([O:10][CH2:11][CH3:12])=[O:9]

参加物

3

反応物 2

HCID 9082Cysteamine HydrochlorideHCID 70211Ethyl oxoacetate

生成物 1

HCID 208627HCID 208627、化合物収率 84.2%

実験手順

22.6 g of mercaptoethylamine hydrochloride and 20.4 g of ethyl glyoxylate are heated with 100 g of 3A molecular sieves on a water bath for 45 min. The mixture is filtered, the filtrate is evaporated in vacuo, the residue is filtered through silica gel and the product is crystallized from methylene chloride/tert.-butyl methyl ether. 27 g of the thiazolidine derivative are obtained. ##STR17##

後処理

  1. filtrationThe mixture is filtered
  2. customthe filtrate is evaporated in vacuo
  3. filtrationthe residue is filtered through silica gel
  4. customthe product is crystallized from methylene chloride/tert.-butyl methyl ether

出典と根拠

ORDレコード
ord-1c073c0a68d941d49834ea0ba172f6cb
出典データセット
uspto-grants-1993_04
特許番号
US05206343

反応ノート

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