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Benzylamine → 2-Propenamide, 3,3-bis(4-methoxyphenyl)-N-(phenylmethyl)-

HRID 1591360
ノート
印刷プレビュー

反応式

HRID 1591360 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[CH:10][C:11]([OH:13])=O)=[CH:5][CH:4]=1.C(N(CC)CC)C.C(Cl)(=O)OCC.[CH2:35]([NH2:42])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>CN(C)C=O.C(OCC)(=O)C>[CH2:35]([NH:42][C:11](=[O:13])[CH:10]=[C:9]([C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=1)[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 7504BenzylamineHCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 12660800HCID 12660800、化合物

生成物 1

HCID 30876662-Propenamide, 3,3-bis(4-methoxyphenyl)-N-(phenylmethyl)-

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒
HCID 8857
Ethyl Acetate
溶媒

実験手順

2.84 g (0.01M) of 3,3-bis(4-methoxyphenyl)acrylic acid was dissolved in 10 ml of dimethylformamide. To the obtained solution, 1.2 g (0.012M) of triethylamine and 1.2 g of ethyl chlorocarbonate were added under icecooling. After one hour, 1.2 g of benzylamine was added thereto and the mixture was stirred at room temperature for one hour. After the completion of the reaction, the reaction mixture was dissolved in 50 ml of ethyl acetate, washed with 10% hydrochloric acid, a saturated aqueous solution of NaHCO3 and a saline solution successively and dried over magnesium sulfate followed by purifying by silica gel column chromatography. Thus 3.3 g of the title compound having the following physicochemical properties was obtained.

後処理

  1. customAfter the completion of the reaction
  2. washwashed with 10% hydrochloric acid
  3. dry with materiala saturated aqueous solution of NaHCO3 and a saline solution successively and dried over magnesium sulfate
  4. customby purifying by silica gel column chromatography
  5. customwas obtained

出典と根拠

ORDレコード
ord-cc8c81c696784b3d85ff112a4a380d9a
出典データセット
uspto-grants-1993_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05206403

反応ノート

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