HCID 69423643、化合物 → HCID 58638700、化合物
反応式
C(OC([CH2:11][NH:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[N:22]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:23][CH2:24][N:25]=2)=[CH:17][CH:16]=1)=O)C1C=CC=CC=1>CO.[Pd]>[CH3:11][NH:12][CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[N:22]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:23][CH2:24][N:25]=2)=[CH:19][CH:20]=1参加物
4
実験手順
A suspension of 4.0 g (9.14 mmol) of tert.-butyl 2-{4-[2-(benzyl-oxycarbonylmethylamino)ethyl]phenyl}4,5-dihydroimidazole-1-carboxylate and 0.4 g of palladium/10% carbon in 80 ml of methanol was hydrogenated in an autoclave for two hours. The catalyst was then filtered off and the filtrate was evaporated to dryness. The crude product obtained in this manner was immediately reacted further without additional purification.
後処理
- filtrationThe catalyst was then filtered off