Triethylamine → 2,3-Dichloro-N-[2-(2-oxoimidazolidin-1-yl)ethyl]benzenesulphonamide

HRID 1591753ノート

反応式

HRID 1591753 の反応式
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9](Cl)(=[O:11])=[O:10].[NH2:13][CH2:14][CH2:15][N:16]1[CH2:20][CH2:19][NH:18][C:17]1=[O:21].C(N(CC)CC)C>O1CCCC1>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9]([NH:13][CH2:14][CH2:15][N:16]1[CH2:20][CH2:19][NH:18][C:17]1=[O:21])(=[O:11])=[O:10]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 80480N-(2-Aminoethyl)ethyleneureaHCID 27342222,3-Dichlorobenzene-1-sulfonyl chloride

生成物 1

HCID 586387222,3-Dichloro-N-[2-(2-oxoimidazolidin-1-yl)ethyl]benzenesulphonamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 0.5 g (2.04 mmol) of 2,3-dichlorobenzenesulphonyl chloride, 0.26 g (2.04 mmol) of 1-(2-aminoethyl)-2-imidazolidone and 1 ml (7.18 mmol) of triethylamine in 10 ml of tetrahydrofuran was stirred at room temperature overnight. The reaction mixture was then washed with 1 N HCl and saturated sodium bicarbonate solution, dried over sodium sulphate and concentrated. The product obtained in this manner was reacted further without additional purification.

後処理

  1. washThe reaction mixture was then washed with 1 N HCl and saturated sodium bicarbonate solution
  2. dry with materialdried over sodium sulphate
  3. concentrationconcentrated
  4. customThe product obtained in this manner
  5. customwas reacted further without additional purification

出典と根拠

ORDレコード
ord-18eb763fb5204c349306c5ee48c1e0dd
出典データセット
uspto-grants-2007_11
特許番号
US07291642B2

反応ノート

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