Sodium Hydroxide → HCID 131726666、化合物
反応式
[OH-].[Na+:2].[F:3][C:4]([F:42])([F:41])[C:5]1[CH:6]=[C:7]([S:15]([NH:18][C:19]2[S:20][C:21]3[CH2:22][N:23]([C:28]4[CH:36]=[C:35]([C:37]([F:40])([F:39])[F:38])[CH:34]=[CH:33][C:29]=4[C:30]([NH2:32])=[O:31])[CH2:24][CH2:25][C:26]=3[N:27]=2)(=[O:17])=[O:16])[CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1>CCO>[Na+:2].[F:42][C:4]([F:3])([F:41])[C:5]1[CH:6]=[C:7]([S:15]([NH:18][C:19]2[S:20][C:21]3[CH2:22][N:23]([C:28]4[CH:36]=[C:35]([C:37]([F:38])([F:39])[F:40])[CH:34]=[CH:33][C:29]=4[C:30]([NH-:32])=[O:31])[CH2:24][CH2:25][C:26]=3[N:27]=2)(=[O:16])=[O:17])[CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1参加物
4
実験手順
1.9 ml of an aqueous 0.1 M NaOH solution are added to a solution of 118 mg of 2-[2-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-6,7-dihydro-4H-thiazolo-[5,4-c]pyridin-5-yl]-4-trifluoromethyl-benzamide in 10 ml of EtOH, and the mixture obtained is stirred at RT for 5 minutes. From the mixture obtained solvent is evaporated and the evaporation residue obtained is subjected to lyophilisation. [2-(3,5-Bis-trifluoromethyl-benzenesulfonylamino)-6,7-dihydro-4H-thiazolo-[5,4-c]pyridin-5-yl]-4-trifluoromethyl-benzamide sodium salt is obtained.