Trifluoroacetic acid → 4-(1,1,4-Trioxo-1,2,5-thiadiazolidin-2-ylmethyl)-benzoic acid 2-ethyl-butyl ester

HRID 1591985ノート

反応式

HRID 1591985 の反応式
[CH2:1]([CH:3]([CH2:34][CH3:35])[CH2:4][O:5][C:6](=[O:33])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][N:14]2[CH2:18][C:17](=[O:19])[N:16](CC3C=CC(OC)=CC=3OC)[S:15]2(=[O:32])=[O:31])=[CH:9][CH:8]=1)[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:34]([CH:3]([CH2:1][CH3:2])[CH2:4][O:5][C:6](=[O:33])[C:7]1[CH:8]=[CH:9][C:10]([CH2:13][N:14]2[CH2:18][C:17](=[O:19])[NH:16][S:15]2(=[O:31])=[O:32])=[CH:11][CH:12]=1)[CH3:35]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 671388714-[5-(2,4-Dimethoxy-benzyl)-1,1,4-trioxo1,2,5-thiadiazolidin-2-ylmethyl]-benzoic acid 2-ethyl-butyl ester

生成物 1

HCID 102155084-(1,1,4-Trioxo-1,2,5-thiadiazolidin-2-ylmethyl)-benzoic acid 2-ethyl-butyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of the title C compound, 4-[5-(2,4-dimethoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl]-benzoic acid 2-ethyl-butyl ester (230 mg, 0.456 mmol) and 2 mL of TFA in 6 mL of CH2Cl2 is stirred at RT overnight. The solvent is evaporated and the residue is treated with MeCN and filtered. The filtrate is concentrated and the residue is treated with Et2O, filtered and the Et2O is evaporated to give 4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl)-benzoic acid 2-ethyl-butyl ester as a light pink colored solid: [M−H]−=353.

後処理

  1. customThe solvent is evaporated
  2. additionthe residue is treated with MeCN
  3. filtrationfiltered
  4. concentrationThe filtrate is concentrated
  5. additionthe residue is treated with Et2O
  6. filtrationfiltered
  7. customthe Et2O is evaporated

出典と根拠

ORDレコード
ord-20e2fd054a0c4b9db4b5aba5756520fc
出典データセット
uspto-grants-2007_11
特許番号
US07291635B2

反応ノート

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