Hydrochloric Acid → 6-Fluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][C:7](=[N:12]O)[CH2:6][CH2:5]2.[ClH:14]>[Pd].CO>[ClH:14].[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([NH2:12])[CH2:6][CH2:5]2参加物
5
実験手順
A mixture of 6-fluoro-3,4-dihydronaphthalen-2(1H)-one oxime (1.58 g, 8.81 mmol), methanol (25 mL), conentrated hydrochloric acid (2 mL) and 10% palladium on charcoal (316 mg) was shaken in a pressure bottle under a hydrogen atmosphere (55 psig). After 18 hours, the mixture was filtered and the solid washed with methanol. The filtrate was concentrated under vacuum, and the residue was washed with ether, dried by concentration from benzene, and dried further under vacuum to provide a white solid (1.48 g, 83%).
後処理
- filtrationthe mixture was filtered
- washthe solid washed with methanol
- concentrationThe filtrate was concentrated under vacuum
- washthe residue was washed with ether
- dry with materialdried by concentration from benzene
- customdried further under vacuum
出典と根拠
- ORDレコード
- ord-585afe5e44ee4a9c8b76bd8f4bd5ae18
- 出典データセット
- uspto-grants-2007_11
- 特許番号
- US07291744B2
反応ノート
読み込み中…