Hydrochloric Acid → 3-((3-Bromophenyl)thio)propanoic acid

HRID 1593031ノート

反応式

HRID 1593031 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([S:8][CH2:9][CH2:10][C:11]([O:13]CC)=[O:12])[CH:5]=[CH:6][CH:7]=1.[OH-].[Na+].Cl>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([S:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 62805311Ethyl 3-[(3-bromophenyl)thio]propanoate

生成物 1

HCID 186867493-((3-Bromophenyl)thio)propanoic acid収率 37.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
20 °C

実験手順

A solution of ethyl 3-[(3-bromophenyl)thio]propanoate (1.15 g) in ethanol (5 ml) was treated with aqueous sodium hydroxide solution (2M, 5 ml) and the mixture was stirred at 20° C. for 15 h. The mixture was acidified with hydrochloric acid and the solution was extracted with ethyl acetate. The organic solution was washed with hydrochloric acid, brine, dried (MgSO4), and evaporated to give the title compound (390 mg) LCMS RT=3.19 min

後処理

  1. extractionthe solution was extracted with ethyl acetate
  2. washThe organic solution was washed with hydrochloric acid, brine
  3. dry with materialdried (MgSO4)
  4. customevaporated

出典と根拠

ORDレコード
ord-44c0eb05cb734f3f88b19ebbeb7929ba
出典データセット
uspto-grants-2007_11
特許番号
US07294650B2

反応ノート

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