2-Chlorobenzylamine → HCID 43445075、化合物

HRID 1593131ノート

反応式

HRID 1593131 の反応式
[N:1](=[C:3]([C:9]([CH3:11])=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5])O.[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH2:16]>C(#N)C>[CH2:7]([O:6][C:4]([C:3]1[N:1]=[C:15]([C:14]2[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=2[Cl:12])[NH:16][C:9]=1[CH3:11])=[O:5])[CH3:8]

参加物

4

反応物 2

HCID 666482-ChlorobenzylamineHCID 178472877HCID 178472877、化合物

生成物 1

HCID 43445075HCID 43445075、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 8.5 g of ethyl 2-oximinoacetoacetate in acetonitrile (100 ml) was added 7.5 ml of 2-chlorobenzylamine. The reaction mixture was then refluxed for 4 hours under argon atmosphere. After such time the reaction mixture was then concentrated in vacuo and the residue was triturated with warm ethylacetate for 10 minutes. After allowing to cool down to room temperature the solid was filtered and dried in vacuo to yield 11.3 g of a white powder, MS (ISP) 265.1 (M+H)+.

後処理

  1. temperatureThe reaction mixture was then refluxed for 4 hours under argon atmosphere
  2. concentrationAfter such time the reaction mixture was then concentrated in vacuo
  3. customthe residue was triturated with warm ethylacetate for 10 minutes
  4. filtrationwas filtered
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-7460c7adaf9049078e767f6f702d0fa5
出典データセット
uspto-grants-2007_11
特許番号
US07294644B2

反応ノート

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