Hydrochloric Acid → Hydrochloric Acid

HRID 1593367

反応式

HRID 1593367 の反応式
[NH:1](C(OCC1C=CC=CC=1)=O)[C@@H:2]([C:13]([NH2:15])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[ClH:26].O>CN(C=O)C.[Pd]>[ClH:26].[NH2:1][C@@H:2]([C:13]([NH2:15])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1

参加物

7

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 853881Z-D-Trp-NH2

生成物 2

HCID 313Hydrochloric AcidHCID 688582D-tryptophanamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 6228Dimethylformamide溶媒

実験手順

Z-D-Trp-NH2 (3 g; 8.9 mmol; 1 eq.) was dissolved in DMF (100 ml). HCl 36% (845 μl; 1.1 eq.), water (2 ml) and palladium on activated charcoal (95 mg, 0.1 eq.) were added to the stirred mixture. The solution was bubbled under hydrogen for 24 hr. When the reaction went to completion, the palladium was filtered on celite. The solvent was removed in vacuo to afford HCl, H-D-Trp-NH2 as a colorless oil.

後処理

  1. customThe solution was bubbled under hydrogen for 24 hr
  2. filtrationthe palladium was filtered on celite
  3. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-0c7c0ca825d1497d922649204cb53b3a
出典データセット
uspto-grants-2007_11
特許番号
US07297681B2

関連ノート

読み込み中…