Sodium Hydroxide → 2-Methylpyrimidine-5-carboxylic acid

HRID 1593384ノート

反応式

HRID 1593384 の反応式
[OH-].[Na+].[CH3:3][C:4]1[N:9]=[CH:8][C:7]([C:10]([O:12]CC)=[O:11])=[CH:6][N:5]=1>C(O)C>[CH3:3][C:4]1[N:9]=[CH:8][C:7]([C:10]([OH:12])=[O:11])=[CH:6][N:5]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 14639203Ethyl 2-methylpyrimidine-5-carboxylate

生成物 1

HCID 136708752-Methylpyrimidine-5-carboxylic acid収率 78.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In 30 ml of ethanol and 20 ml of a 1M sodium hydroxide aqueous solution, 2.9 g of ethyl 2-methylpyrimidine-5-carboxylate was stirred for 2 hours. The solvent was removed by evaporation and an appropriate amount of water and diethyl ether were added thereto, followed by liquid-separating operation. The resulting aqueous layer was made weakly acidic with a 1M hydrochloric acid aqueous solution and then the resulting crystals were collected by filtration, washed with water, and then dried to obtain 1.9 g of the title compound.

後処理

  1. customThe solvent was removed by evaporation
  2. additionan appropriate amount of water and diethyl ether were added
  3. customby liquid-separating operation
  4. filtrationthe resulting crystals were collected by filtration
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-30401727b2c744078950f7a1fde32c60
出典データセット
uspto-grants-2007_11
特許番号
US07297698B2

反応ノート

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