2-chloro-6-nitroquinoxaline → 2-Methoxy-6-nitroquinoxaline
反応式
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=2)[N:3]=1.[CH3:15][O-:16].[Na+]>C1COCC1>[CH3:15][O:16][C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=2)[N:3]=1参加物
4
実験手順
Into 10 ml of THF was dissolved 1.16 g of 2-chloro-6-nitroquinoxaline, and then 1.0 g of sodium methoxide was added thereto, followed by heating under refluxing for 30 minutes. Then, the solvent was removed by evaporation. Water was added to the residue, followed by extraction with ethyl acetate. The organic layer was washed with saturated saline. After the solvent was removed by evaporation, the residue was crystallized from diethyl ether-hexane to obtain 776 mg of the title compound.
後処理
- temperatureby heating
- temperatureunder refluxing for 30 minutes
- customThen, the solvent was removed by evaporation
- additionWater was added to the residue
- extractionfollowed by extraction with ethyl acetate
- washThe organic layer was washed with saturated saline
- customAfter the solvent was removed by evaporation
- customthe residue was crystallized from diethyl ether-hexane
出典と根拠
- ORDレコード
- ord-202290a4615c44c58380737706d7e9a0
- 出典データセット
- uspto-grants-2007_11
- 特許番号
- US07297698B2
反応ノート
読み込み中…