Ammonia → 7-Azatryptamine
反応式
Cl[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[I-].[Na+].[NH3:15]>CO>[NH:6]1[C:7]2=[N:8][CH:9]=[CH:10][CH:11]=[C:12]2[C:4]([CH2:3][CH2:2][NH2:15])=[CH:5]1参加物
5
反応条件
- 温度
- 60 °C
実験手順
A mixture of 3-(2-Chloroethyl)-1H-pyrrolo[2,3-b]pyridine (4.0 g) and sodium iodide (3.2 g, 0.95 eq.) in a solution of ammonia in methanol (7 N, 20 mL) is heated to 60° C. in a Fischer-Porter sealed pressure bottle for 48 h. The bottle is cooled, opened cautiously and the solvent removed in vacuo. The resultant residue is recrystallized from THF to give the title ethylamine compound as a tan solid, 4.8 g, identified by HPLC and mass spectral analyses.
後処理
- customsealed pressure bottle for 48 h
- temperatureThe bottle is cooled
- customthe solvent removed in vacuo
- customThe resultant residue is recrystallized from THF
出典と根拠
- ORDレコード
- ord-b07198e899884a3090e0ca153e172f6f
- 出典データセット
- uspto-grants-2007_11
- 特許番号
- US07297705B2
反応ノート
読み込み中…