Triethylamine → 919482-29-4
反応式
[CH3:1][C:2]1([CH3:8])[O:6][CH2:5][CH:4]([OH:7])[O:3]1.[CH2:9](N(CC)CC)C.[CH3:16][S:17](Cl)(=[O:19])=[O:18].[Cl-].[NH4+]>O1CCCC1>[CH3:16][S:17]([O:7][CH:4]1[CH2:5][O:6][C:2]([CH3:8])([CH3:1])[O:3][CH2:9]1)(=[O:19])=[O:18]参加物
6
実験手順
A 2,2-dimethyl-1,3-dioxolan-5-ol (743 mg) solution in tetrahydrofuran (10 mL) was cooled to 0° C. in nitrogen atmosphere. To the reaction mixture, triethylamine (1.87 mL) and methanesulfonyl chloride (520 μL) were successively added at 0° C., followed by 30 minutes' stirring. After addition of saturated aqueous ammonium chloride solution, the reaction mixture was extracted with ethyl acetate. The extract washed with saturated brine, dried over anhydrous magnesium sulfate and the solvent was removed by distillation to provide 837 mg of crude title compound as a colorless solid.
後処理
- extractionthe reaction mixture was extracted with ethyl acetate
- washThe extract washed with saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- customthe solvent was removed by distillation
出典と根拠
- ORDレコード
- ord-5994f08bc24b4279a61f0e779823fb82
- 出典データセット
- uspto-grants-2007_11
- 特許番号
- US07300947B2
反応ノート
読み込み中…