Hydrazine → [2,4'-Bipyridin]-5-amine

HRID 1594386ノート

反応式

HRID 1594386 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[N:8][CH:9]=1)([O-])=O.NN>[Pd].C(O)C>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[N:8][CH:9]=1

参加物

5

反応物 2

HCID 9321HydrazineHCID 111832665-nitro-2,4'-bipyridine

生成物 1

HCID 45788763[2,4'-Bipyridin]-5-amine収率 95%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

5-Nitro-2,4′-bipyridine (10 g) obtained in Example 1 was added to ethanol (400 ml). 10% Pd—C (50% wet with water) (0.14 g) was added, and then, hydrazine.monohydrate (10 g) was dropwise added, for reflux under heating for 3 hours. The reaction solution was filtered and concentrated. The resulting crystal was recrystallized in ethyl acetate, to obtain the object substance (8.13 g; yield of 95%).

後処理

  1. temperaturefor reflux
  2. temperatureunder heating for 3 hours
  3. filtrationThe reaction solution was filtered
  4. concentrationconcentrated
  5. customThe resulting crystal was recrystallized in ethyl acetate
  6. customto obtain the object substance (8.13 g; yield of 95%)

出典と根拠

ORDレコード
ord-61da0351d59f4790a6623ea520f41c84
出典データセット
uspto-grants-2007_11
特許番号
US07301029B2

反応ノート

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