Aluminium lithium hydride → N9-phenethyl-8-hydroxymethyladenine
反応式
[CH2:1]([N:9]1[C:17]([C:18](OC)=[O:19])=[N:16][C:15]2[C:10]1=[N:11][CH:12]=[N:13][C:14]=2[NH2:22])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:1]([N:9]1[C:17]([CH2:18][OH:19])=[N:16][C:15]2[C:10]1=[N:11][CH:12]=[N:13][C:14]=2[NH2:22])[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1参加物
4
実験手順
A solution of N9-phenethyl-8-methoxycarbonyladenine (1 mmol) in tetrahydrofuran was treated with lithium aluminum hydride (1 mmol) at 0° C. for 1 h. Extraction and chromatography gave N9-phenethyl-8-hydroxymethyl-adenine as a white solid. TLC: Rf=0.31, 10% MeOH—CH2Cl2.
後処理
- extractionExtraction and chromatography
出典と根拠
- ORDレコード
- ord-ca9ecbfe7b2d49d98e6758dad26748b4
- 出典データセット
- uspto-grants-2001_09
- 特許番号
- US06284748B1
反応ノート
読み込み中…