Bis(2-bromoethyl) ether → 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-[2-methyl-5-(2-morpholin-4-yl-ethyl)-imidazol-1-ylmethyl]-benzonitrile

HRID 1594863ノート

反応式

HRID 1594863 の反応式
Cl.Cl.[NH2:3][CH2:4][CH2:5][C:6]1[N:10]([CH2:11][C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[C:14]([O:20][C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([C:27]4([CH2:36][CH3:37])[CH2:33][CH2:32][CH2:31][CH2:30][N:29]([CH3:34])[C:28]4=[O:35])[CH:22]=3)[CH:13]=2)[C:9]([CH3:38])=[N:8][CH:7]=1.Br[CH2:40][CH2:41][O:42][CH2:43][CH2:44]Br>C(#N)C.C(N(CC)CC)C>[CH2:36]([C:27]1([C:23]2[CH:22]=[C:21]([CH:26]=[CH:25][CH:24]=2)[O:20][C:14]2[CH:13]=[C:12]([CH2:11][N:10]3[C:6]([CH2:5][CH2:4][N:3]4[CH2:44][CH2:43][O:42][CH2:41][CH2:40]4)=[CH:7][N:8]=[C:9]3[CH3:38])[CH:19]=[CH:18][C:15]=2[C:16]#[N:17])[CH2:33][CH2:32][CH2:31][CH2:30][N:29]([CH3:34])[C:28]1=[O:35])[CH3:37]

参加物

5

反応物 2

HCID 21521Bis(2-bromoethyl) etherHCID 217062014-[5-(2-Amino-ethyl)-2-methyl-imidazol-1-ylmethyl]-2-[3-(3-ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-benzonitrile dihydrochloride

生成物 1

HCID 98077692-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-[2-methyl-5-(2-morpholin-4-yl-ethyl)-imidazol-1-ylmethyl]-benzonitrile

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒HCID 8471Triethylamine溶媒

実験手順

To a solution of 4-[5-(2-amino-ethyl)-2-methyl-imidazol-1-ylmethyl]-2-[3-(3-ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-benzonitrile dihydrochloride (as described in Example 11) (0.25 g, 0.456 mmol) in acetonitrile (35.0 mL) and triethylamine (1.8 mL) was added 2-bromoethyl ether (0.133 mL, 1.06 mmol) and the mixture was refluxed for 48 hr. The solvents were removed in vacuo to obtain the title compound after purification by preparative HPLC.

後処理

  1. temperaturethe mixture was refluxed for 48 hr
  2. customThe solvents were removed in vacuo

出典と根拠

ORDレコード
ord-aa3eb88c8e6c445794e16d41429514f0
出典データセット
uspto-grants-2001_09
特許番号
US06284755B1

反応ノート

読み込み中…